![]() Autopsy reports from fatal cases of AFE report epithelial squamous cells, lanugo hair, and fat from vernix or infantile mucin in the maternal pulmonary vasculature. The clinical syndrome itself is precipitated when amniotic fluid is able to breach the physical barrier between the maternal and fetal environments as a result of uterine trauma. These three contributory pathways are: (a) mechanical obstruction of vessels caused by AFE (b) a subsequent inflammatory effect by AFE on the maternal circulatory system and (c) an as of yet poorly understood immunologic mechanism. Pathophysiology of amniotic fluid embolismĪmniotic fluid embolism syndrome is thought to occur through three different pathophysiologic mechanisms. We also highlight the critical care aspects of affected patient care, and focus on the high index of clinical suspicion required to promptly recognize and treat this cause of 10-26% of maternal deaths. In this review we discuss the pathophysiology, clinical presentation, and diagnostic and therapeutic considerations associated with AFE. ![]() Although specialists in obstetrics are the most likely to encounter this clinical entity emergency medicine physicians, surgeons, anesthesiologists, and intensivists should also be familiar with the diagnosis and management of AFE. ![]() Due to the uncommon occurrence of AFE the need exists for a high level of clinical suspicion among practitioners. The reported incidence of AFE is between 0.001% and 0.013% among patients admitted for delivery. Its first modern description was published in the 1920's with a further report recognizing AFE as a syndrome in the 1940s. Clinical sequelae of this unpredictable and unpreventable entity are often devastating with significant associated morbidity and mortality. The key factors for successful management and resolution of this disease process continue to be sharp vigilance, a high level of clinical suspicion, and rapid all-out resuscitative efforts on the part of all clinicians involved in the medical care of the parturient.Īmniotic fluid embolism (AFE) is a rare event that affects parturients during delivery or in the immediate postpartum period. ![]() Special attention is paid to the modern aggressive supportive care that resulted in an overall reduction in the still alarmingly high mortality rate of this devastating entity. In this review the current state of medical knowledge about AFE is outlined including its incidence, risk factors, diagnosis, pathophysiology, and clinical manifestations. However, this rare occurrence carries a high probability of serious sequelae including cardiac arrest, ARDS, coagulopathy with massive hemorrhage, encephalopathy, seizures, and both maternal and infant mortality. With its low incidence it is unlikely that any given practitioner will be confronted with a case of AFE. This project is sustainable by the annual use of the PowerPoint for training and continued review outcomes of suspected AFE cases.Amniotic fluid embolism (AFE) is an unpredictable and as-of-yet unpreventable complication of maternity. After completing the PowerPoint presentation, a post-test was administered following the same format to all 20 nurses to assess key symptoms of AFE, ability to recognize treatment pathways and monitoring recommendations. An 8-question pre-test was given to assess knowledge of AFE, and a PowerPoint presentation highlighting the key presenting symptoms, monitoring, and treatment pathway. After a literature review, a teaching session was developed and implemented as part of the annual training for 20 nursing staff at a small 50-bed rural hospital in central California. Amniotic fluid embolism (AFE) is a rare medical emergency that requires healthcare providers to rapidly diagnose, monitor, and treat the sequela of resulting symptoms in the obstetric patient. Healthcare providers in these rural settings often lack the staffing and experience to effectively recognize and treat rare obstetric emergencies. Access to care in rural areas can prove difficult for any patient, but especially for the expecting mother.
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